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Pancrelipase

August 1st 2006 01:11
Pancrelipase :
This medication is a combination of specific digestive (pancreatic) enzymes obtained from pigs. These enzymes aid in the digestion and absorption of starches and fats. Pancrelipase is used in the treatment of various pancreatic-enzyme deficiencies resulting from conditions such as pancreatitis, cystic fibrosis, or gastrointestinal bypass surgery.

Treatment :
To obtain the maximum benefit, take pancrelipase just before or with meals or snacks. The powder can be added to food; the tablets can be crushed and mixed with food.

If you are taking the capsules containing the enteric-coated microspheres, swallow the capsules whole. Chewing, crushing, or breaking the capsules decreases their effectiveness and increases the side effects. However, if you have difficulty swallowing the capsules, you can open them and sprinkle the contents on a small amount of liquid or soft food, which you should then swallow without chewing. Do not mix this medication with alkaline foods (such as dairy products); they can reduce its effectiveness.


If you miss a dose of this medication, do not take the missed dose at all; just return to your regular dosing schedule. Do not double the next dose.

Side Effects :

Minor: Diarrhea, nausea, or stomach cramps. These side effects should disappear over time as your body adjusts to the medication.

Major: Tell your doctor about any side effects you experience that are persistent or particularly bothersome. IT IS ESPECIALLY IMPORTANT TO TELL YOUR DOCTOR about bloody urine, hives, joint pain, shortness of breath, skin rash, or swelling of the feet.

Warnings :

Tell your doctor about unusual or allergic reactions you have had to any medications, especially to pancrelipase, pancreatin, or any other digestive enzymes.

Patients who have allergies to pork products may also be allergic to pancrelipase, since it is obtained from pigs.
Since pancrelipase may reduce the absorption of iron, an iron supplement may be needed. Talk to your doctor about whether an iron supplement would be appropriate for you during treatment with pancreatin.
The powder form as well as the powder from opened capsules of this medication can be very irritating to the nose and throat. Avoid inhaling the particles.
Be sure to tell your doctor if you are pregnant. Although pancrelipase appears to be safe during pregnancy, extensive studies have not been conducted. Also tell your doctor if you are breast-feeding an infant. It is not known whether pancrelipase passes into breast milk.
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