Summer BanksGlyburide and working
December 10th 2006 07:22
Glyburide and working :
Glyburide is used for the treatment of diabetes mellitus that usually appears in adulthood (this type of diabetes is referred to as type 2 diabetes, or non-insulin-dependent diabetes) that cannot be managed by control of diet alone. Glyburide lowers blood sugar levels by increasing the release of insulin from the pancreas.
Glyburide Facts
Brand names (manufacturers): DiaBeta (Hoechst); glyburide (various manufacturers); Glynase Prestabs (Pharmacia); Micronase (Pharmacia); micronized glyburide (various manufacturers)
Type of drug: Oral antidiabetic
Ingredient: Glyburide
Dosage forms: Tablets (1.25 mg, 2.5 mg, and 5 mg); tablets, micronized (1.5 mg, 3 mg, and 6 mg)
Storage: Store this medication at room temperature in a tightly closed container.
Treatment :
Take glyburide with a meal, usually breakfast or the first main meal of the day.
For glyburide to work correctly, it must be taken as directed by your doctor. To maintain a constant blood sugar level, it is best to take this medication at the same time(s) each day. It is therefore important to try not to miss any doses of glyburide. If you do miss a dose, take it as soon as possible. However, if it is almost time for the next dose, do not take the missed dose at all; just return to your regular dosing schedule. Do not double the next dose. Tell your doctor if you feel any side effects from missing a dose of this medication.
People with diabetes who are taking oral antidiabetic medication may need to be switched to insulin if they develop diabetic coma, have a severe infection, are scheduled for major surgery, or become pregnant.
Side Effects :
Minor: Diarrhea, headache, heartburn, loss of appetite, nausea, stomach discomfort, stomach pain, or vomiting. The side effects from glyburide will most likely disappear during treatment as your body adjusts to the medicine.
Glyburide may increase your sensitivity to sunlight. It is therefore important to use caution during exposure to the sun. You may want to wear protective clothing and sunglasses. Use an effective sunscreen, and avoid exposure to sunlamps.
More Information
on Diabetes
Medications are only one aspect of diabetes and its treatment. Here are links to articles that explore the disease in detail:
How to Adjust to Life With Diabetes
Major: Notify your doctor if any side effects are persistent or particularly bothersome. IT IS ESPECIALLY IMPORTANT TO TELL YOUR DOCTOR about dark urine, fatigue, itching of the skin, light-colored stools, rash, sore throat and fever, unusual bleeding or bruising, or yellowing of the eyes or skin.
Interactions
Glyburide interacts with a number of other medications:
Glyburide can lower blood sugar levels, sometimes dangerously so, when it is combined with cimetidine, ranitidine, ciprofloxacin, guanethidine, monoamine oxidase (MAO) inhibitors, quinidine, quinine, salicylates, chloramphenicol, and antifungal agents (such as fluconazole).
Thyroid hormones, dextrothyroxine, epinephrine, lithium, phenytoin, thiazide diuretics (water pills), and cortisonelike medications (such as dexamethasone, hydrocortisone, prednisone), combined with glyburide, can actually increase blood sugar levels.
Antidiabetic medications can increase the effects of warfarin, which can lead to bleeding complications.
Beta-blocking medications (such as atenolol, metoprolol, nadolol, pindolol, propranolol, and timolol), combined with glyburide, can result in either high or low blood sugar levels. Beta blockers can also mask the symptoms of low blood sugar, which can be dangerous.
Blood levels of cyclosporine may be increased with glyburide, increasing the risk of side effects from cyclosporine.
BE SURE TO TELL YOUR DOCTOR if you are already taking any of the medications listed above.
Warnings :
Tell your doctor if you have ever had unusual or allergic reactions to medications, especially to glyburide or to any sulfa medication, including sulfonamide antibiotics, diuretics (water pills), or other oral antidiabetics.
Tell your doctor if you now have or ever had kidney disease, liver disease, thyroid disease, or a severe infection.
Follow the special dietary instructions that your doctor gave you. This is an important part of controlling your blood sugar levels and is necessary for this medicine to work properly.
Avoid drinking alcoholic beverages while taking this medication (unless otherwise directed by your doctor). Some patients who take this medicine experience nausea, vomiting, dizziness, stomach pain, pounding headache, sweating, and redness of the face and skin when they drink alcohol, and large amounts of alcohol can lower blood sugar to dangerously low levels.
Be sure to tell your doctor or dentist that you are taking this medication before having any kind of surgery or other medical or dental treatment.
Test for sugar in your urine as directed by your doctor. It is a convenient way to determine whether or not your diabetes is being controlled by this medicine.
Eat or drink something containing sugar right away if you experience any symptoms of low blood sugar (such as anxiety, chills, cold sweats, cool or pale skin, drowsiness, excessive hunger, headache, nausea, nervousness, rapid heartbeat, shakiness, or unusual tiredness or weakness). It is also important that your family and friends recognize the symptoms of low blood sugar and know what to do if they observe any of these symptoms in you. Also, check with your doctor as soon as possible -- even if these symptoms are corrected by the sugar. The blood-sugar-lowering effects of this medicine can last for hours, and the symptoms may return during this period. Good sources of sugar are orange juice, corn syrup, honey, sugar cubes, and table sugar. You are at greatest risk of developing low blood sugar if you skip or delay meals, exercise more than usual, cannot eat because of nausea or vomiting, or drink large amounts of alcohol.
Be sure to tell your doctor if you are pregnant. Studies of this drug taken in human pregnancy have not yet been completed, but studies in animals have shown it can cause birth defects. Consult your doctor if you are nursing an infant.
Glyburide is used for the treatment of diabetes mellitus that usually appears in adulthood (this type of diabetes is referred to as type 2 diabetes, or non-insulin-dependent diabetes) that cannot be managed by control of diet alone. Glyburide lowers blood sugar levels by increasing the release of insulin from the pancreas.
Glyburide Facts
Brand names (manufacturers): DiaBeta (Hoechst); glyburide (various manufacturers); Glynase Prestabs (Pharmacia); Micronase (Pharmacia); micronized glyburide (various manufacturers)
Type of drug: Oral antidiabetic
Ingredient: Glyburide
Dosage forms: Tablets (1.25 mg, 2.5 mg, and 5 mg); tablets, micronized (1.5 mg, 3 mg, and 6 mg)
Storage: Store this medication at room temperature in a tightly closed container.
Treatment :
Take glyburide with a meal, usually breakfast or the first main meal of the day.
For glyburide to work correctly, it must be taken as directed by your doctor. To maintain a constant blood sugar level, it is best to take this medication at the same time(s) each day. It is therefore important to try not to miss any doses of glyburide. If you do miss a dose, take it as soon as possible. However, if it is almost time for the next dose, do not take the missed dose at all; just return to your regular dosing schedule. Do not double the next dose. Tell your doctor if you feel any side effects from missing a dose of this medication.
People with diabetes who are taking oral antidiabetic medication may need to be switched to insulin if they develop diabetic coma, have a severe infection, are scheduled for major surgery, or become pregnant.
Side Effects :
Minor: Diarrhea, headache, heartburn, loss of appetite, nausea, stomach discomfort, stomach pain, or vomiting. The side effects from glyburide will most likely disappear during treatment as your body adjusts to the medicine.
Glyburide may increase your sensitivity to sunlight. It is therefore important to use caution during exposure to the sun. You may want to wear protective clothing and sunglasses. Use an effective sunscreen, and avoid exposure to sunlamps.
More Information
on Diabetes
Medications are only one aspect of diabetes and its treatment. Here are links to articles that explore the disease in detail:
How to Adjust to Life With Diabetes
Major: Notify your doctor if any side effects are persistent or particularly bothersome. IT IS ESPECIALLY IMPORTANT TO TELL YOUR DOCTOR about dark urine, fatigue, itching of the skin, light-colored stools, rash, sore throat and fever, unusual bleeding or bruising, or yellowing of the eyes or skin.
Interactions
Glyburide interacts with a number of other medications:
Glyburide can lower blood sugar levels, sometimes dangerously so, when it is combined with cimetidine, ranitidine, ciprofloxacin, guanethidine, monoamine oxidase (MAO) inhibitors, quinidine, quinine, salicylates, chloramphenicol, and antifungal agents (such as fluconazole).
Thyroid hormones, dextrothyroxine, epinephrine, lithium, phenytoin, thiazide diuretics (water pills), and cortisonelike medications (such as dexamethasone, hydrocortisone, prednisone), combined with glyburide, can actually increase blood sugar levels.
Antidiabetic medications can increase the effects of warfarin, which can lead to bleeding complications.
Beta-blocking medications (such as atenolol, metoprolol, nadolol, pindolol, propranolol, and timolol), combined with glyburide, can result in either high or low blood sugar levels. Beta blockers can also mask the symptoms of low blood sugar, which can be dangerous.
Blood levels of cyclosporine may be increased with glyburide, increasing the risk of side effects from cyclosporine.
BE SURE TO TELL YOUR DOCTOR if you are already taking any of the medications listed above.
Warnings :
Tell your doctor if you have ever had unusual or allergic reactions to medications, especially to glyburide or to any sulfa medication, including sulfonamide antibiotics, diuretics (water pills), or other oral antidiabetics.
Tell your doctor if you now have or ever had kidney disease, liver disease, thyroid disease, or a severe infection.
Follow the special dietary instructions that your doctor gave you. This is an important part of controlling your blood sugar levels and is necessary for this medicine to work properly.
Avoid drinking alcoholic beverages while taking this medication (unless otherwise directed by your doctor). Some patients who take this medicine experience nausea, vomiting, dizziness, stomach pain, pounding headache, sweating, and redness of the face and skin when they drink alcohol, and large amounts of alcohol can lower blood sugar to dangerously low levels.
Be sure to tell your doctor or dentist that you are taking this medication before having any kind of surgery or other medical or dental treatment.
Test for sugar in your urine as directed by your doctor. It is a convenient way to determine whether or not your diabetes is being controlled by this medicine.
Eat or drink something containing sugar right away if you experience any symptoms of low blood sugar (such as anxiety, chills, cold sweats, cool or pale skin, drowsiness, excessive hunger, headache, nausea, nervousness, rapid heartbeat, shakiness, or unusual tiredness or weakness). It is also important that your family and friends recognize the symptoms of low blood sugar and know what to do if they observe any of these symptoms in you. Also, check with your doctor as soon as possible -- even if these symptoms are corrected by the sugar. The blood-sugar-lowering effects of this medicine can last for hours, and the symptoms may return during this period. Good sources of sugar are orange juice, corn syrup, honey, sugar cubes, and table sugar. You are at greatest risk of developing low blood sugar if you skip or delay meals, exercise more than usual, cannot eat because of nausea or vomiting, or drink large amounts of alcohol.
Be sure to tell your doctor if you are pregnant. Studies of this drug taken in human pregnancy have not yet been completed, but studies in animals have shown it can cause birth defects. Consult your doctor if you are nursing an infant.
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