katyzzzGlipizide and working
December 10th 2006 07:03
Glipizide and working :
Glipizide is used in the treatment of type 2 diabetes mellitus (sometimes called non-insulin-dependent, or adult-onset, diabetes) that cannot be managed by control of diet alone. Glipizide lowers blood sugar levels by increasing the release of insulin from the pancreas.
Glipizide Facts
Brand names (manufacturers): Glipizide (various manufacturers); Glucotrol (Pfizer); Glucotrol XL (Pfizer)
Type of drug: Oral antidiabetic
Ingredient: Glipizide
Dosage forms: Tablets (5 mg and 10 mg); tablets, XL (2.5 mg, 5 mg, and 10 mg)
Storage: Store at room temperature in a tightly closed container.
Treatment :
Glipizide should be taken on an empty stomach 30 minutes before a meal, unless your doctor directs you to do otherwise.
Swallow the XL tablets whole; do not chew or crush them.
It is important to try not to miss any doses of this medication. If you do miss a dose, take it as soon as possible. However, if it is almost time for the next dose, do not take the missed dose at all; just return to your regular dosing schedule. Do not double the next dose. Tell your doctor if you feel any side effects from missing a dose of this drug.
People with diabetes who are taking oral antidiabetic medication may need to be switched to insulin if they develop diabetic coma, have a severe infection, are scheduled for major surgery, or become pregnant.
Side Effects :
Minor: Diarrhea, headache, heartburn, loss of appetite, nausea, stomach discomfort, stomach pain, or vomiting. These side effects usually go away during treatment, as your body adjusts to the medicine.
More Information on Diabetes Medications are only one aspect of diabetes and its treatment. Here are links to articles that explore the disease in detail:
How to Adjust to Life With Diabetes :
Glipizide may increase your sensitivity to sunlight. It is therefore important to use caution during exposure to the sun. Wear protective clothing and use an effective sunscreen outdoors during the day, and avoid exposure to sunlamps.
Major: If any side effects are persistent or particularly bothersome, it is important to notify your doctor. IT IS ESPECIALLY IMPORTANT TO TELL YOUR DOCTOR about dark urine, fatigue, itching of the skin, light-colored stools, rash, sore throat and fever, unusual bleeding or bruising, or yellowing of the eyes or skin.
Interactions :
Glipizide interacts with a number of other medications:
Glipizide can lower blood sugar levels, sometimes dangerously so, when it is combined with cimetidine, ranitidine, ciprofloxacin, guanethidine, monoamine oxidase (MAO) inhibitors, quinidine, quinine, salicylates, chloramphenicol, and antifungal agents (such as fluconazole).
Thyroid hormones; dextrothyroxine; epinephrine; lithium; phenytoin; thiazide diuretics (water pills); and cortisonelike medications (such as dexamethasone, hydrocortisone, prednisone), combined with glipizide, can actually increase blood sugar levels -- just what you are trying to avoid.
Antidiabetic medications can increase the effects of warfarin, which can lead to bleeding complications.
Beta-blocking medications (atenolol, metoprolol, nadolol, pindolol, propranolol, and timolol), combined with glipizide, can result in either high or low blood sugar levels. Beta blockers can also mask the symptoms of low blood sugar, which can be dangerous.
Glipizide can increase the blood levels of cyclosporine, increasing the risk of side effects from cyclosporine.
BE SURE TO TELL YOUR DOCTOR if you are already taking any of the medications listed above.
Warnings :
It is important to tell your doctor if you have ever had any unusual or allergic reaction to this medicine or to any sulfa medication, including sulfonamide antibiotics, diuretics (water pills), or other oral antidiabetics.
It is also important to tell your doctor if you now have or ever had kidney disease, liver disease, severe infection, or thyroid disease.
Avoid drinking alcoholic beverages while taking this medication (unless directed otherwise by your doctor). Some patients who take this medicine experience nausea, vomiting, dizziness, stomach pain, pounding headache, sweating, and redness of the face and skin when they drink alcohol, and large amounts of alcohol can lower blood sugar to dangerously low levels.
Follow the special diet that your doctor gave you. This is an important part of controlling your blood sugar and is necessary for this medicine to work properly.
Be sure to tell your doctor or dentist that you are taking this medicine before having any kind of surgery or other medical or dental treatment.
Test for sugar in your urine as directed by your doctor. It is a convenient way to determine whether or not your diabetes is being controlled by this medicine.
Eat or drink something containing sugar right away if you experience any symptoms of low blood sugar (such as anxiety, chills, cold sweats, cool or pale skin, drowsiness, excessive hunger, headache, nausea, nervousness, rapid heartbeat, shakiness, or unusual tiredness or weakness). It is important that your family and friends know the symptoms of low blood sugar and what to do if they recognize any of these symptoms in you. Also, check with your doctor as soon as possible -- even if these symptoms are corrected by the sugar. The blood-sugar-lowering effects of this medicine can last for hours, and the symptoms may return during this period. Good sources of sugar are orange juice, corn syrup, honey, sugar cubes, and table sugar. You are at greatest risk of developing low blood sugar if you skip or delay meals, exercise more than usual, cannot eat because of nausea or vomiting, or drink large amounts of alcohol.
Be sure to tell your doctor if you are pregnant. Studies have not yet been completed in humans, but studies in animals have shown that this medicine can cause birth defects. Also tell your doctor if you are breast-feeding an infant. Small amounts of glipizide pass into breast milk.
Glipizide is used in the treatment of type 2 diabetes mellitus (sometimes called non-insulin-dependent, or adult-onset, diabetes) that cannot be managed by control of diet alone. Glipizide lowers blood sugar levels by increasing the release of insulin from the pancreas.
Glipizide Facts
Brand names (manufacturers): Glipizide (various manufacturers); Glucotrol (Pfizer); Glucotrol XL (Pfizer)
Type of drug: Oral antidiabetic
Ingredient: Glipizide
Dosage forms: Tablets (5 mg and 10 mg); tablets, XL (2.5 mg, 5 mg, and 10 mg)
Storage: Store at room temperature in a tightly closed container.
Treatment :
Glipizide should be taken on an empty stomach 30 minutes before a meal, unless your doctor directs you to do otherwise.
Swallow the XL tablets whole; do not chew or crush them.
It is important to try not to miss any doses of this medication. If you do miss a dose, take it as soon as possible. However, if it is almost time for the next dose, do not take the missed dose at all; just return to your regular dosing schedule. Do not double the next dose. Tell your doctor if you feel any side effects from missing a dose of this drug.
People with diabetes who are taking oral antidiabetic medication may need to be switched to insulin if they develop diabetic coma, have a severe infection, are scheduled for major surgery, or become pregnant.
Side Effects :
Minor: Diarrhea, headache, heartburn, loss of appetite, nausea, stomach discomfort, stomach pain, or vomiting. These side effects usually go away during treatment, as your body adjusts to the medicine.
More Information on Diabetes Medications are only one aspect of diabetes and its treatment. Here are links to articles that explore the disease in detail:
How to Adjust to Life With Diabetes :
Glipizide may increase your sensitivity to sunlight. It is therefore important to use caution during exposure to the sun. Wear protective clothing and use an effective sunscreen outdoors during the day, and avoid exposure to sunlamps.
Major: If any side effects are persistent or particularly bothersome, it is important to notify your doctor. IT IS ESPECIALLY IMPORTANT TO TELL YOUR DOCTOR about dark urine, fatigue, itching of the skin, light-colored stools, rash, sore throat and fever, unusual bleeding or bruising, or yellowing of the eyes or skin.
Interactions :
Glipizide interacts with a number of other medications:
Glipizide can lower blood sugar levels, sometimes dangerously so, when it is combined with cimetidine, ranitidine, ciprofloxacin, guanethidine, monoamine oxidase (MAO) inhibitors, quinidine, quinine, salicylates, chloramphenicol, and antifungal agents (such as fluconazole).
Thyroid hormones; dextrothyroxine; epinephrine; lithium; phenytoin; thiazide diuretics (water pills); and cortisonelike medications (such as dexamethasone, hydrocortisone, prednisone), combined with glipizide, can actually increase blood sugar levels -- just what you are trying to avoid.
Antidiabetic medications can increase the effects of warfarin, which can lead to bleeding complications.
Beta-blocking medications (atenolol, metoprolol, nadolol, pindolol, propranolol, and timolol), combined with glipizide, can result in either high or low blood sugar levels. Beta blockers can also mask the symptoms of low blood sugar, which can be dangerous.
Glipizide can increase the blood levels of cyclosporine, increasing the risk of side effects from cyclosporine.
BE SURE TO TELL YOUR DOCTOR if you are already taking any of the medications listed above.
Warnings :
It is important to tell your doctor if you have ever had any unusual or allergic reaction to this medicine or to any sulfa medication, including sulfonamide antibiotics, diuretics (water pills), or other oral antidiabetics.
It is also important to tell your doctor if you now have or ever had kidney disease, liver disease, severe infection, or thyroid disease.
Avoid drinking alcoholic beverages while taking this medication (unless directed otherwise by your doctor). Some patients who take this medicine experience nausea, vomiting, dizziness, stomach pain, pounding headache, sweating, and redness of the face and skin when they drink alcohol, and large amounts of alcohol can lower blood sugar to dangerously low levels.
Follow the special diet that your doctor gave you. This is an important part of controlling your blood sugar and is necessary for this medicine to work properly.
Be sure to tell your doctor or dentist that you are taking this medicine before having any kind of surgery or other medical or dental treatment.
Test for sugar in your urine as directed by your doctor. It is a convenient way to determine whether or not your diabetes is being controlled by this medicine.
Eat or drink something containing sugar right away if you experience any symptoms of low blood sugar (such as anxiety, chills, cold sweats, cool or pale skin, drowsiness, excessive hunger, headache, nausea, nervousness, rapid heartbeat, shakiness, or unusual tiredness or weakness). It is important that your family and friends know the symptoms of low blood sugar and what to do if they recognize any of these symptoms in you. Also, check with your doctor as soon as possible -- even if these symptoms are corrected by the sugar. The blood-sugar-lowering effects of this medicine can last for hours, and the symptoms may return during this period. Good sources of sugar are orange juice, corn syrup, honey, sugar cubes, and table sugar. You are at greatest risk of developing low blood sugar if you skip or delay meals, exercise more than usual, cannot eat because of nausea or vomiting, or drink large amounts of alcohol.
Be sure to tell your doctor if you are pregnant. Studies have not yet been completed in humans, but studies in animals have shown that this medicine can cause birth defects. Also tell your doctor if you are breast-feeding an infant. Small amounts of glipizide pass into breast milk.
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