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Delavirdine

November 10th 2006 01:22
Delavirdine :
Delavirdine is used in the treatment of human immunodeficiency virus (HIV) infection. HIV is the virus that causes AIDS. Delavirdine works by inhibiting the reproduction, or growth, of the virus, which slows the progression of AIDS. Delavirdine does not cure HIV infection or AIDS, but it may delay onset of other infections and diseases caused by AIDS

Treatment :
Delavirdine works best when the level of medicine in your bloodstream is kept constant. It is best to take the drug at evenly spaced intervals throughout the day. To avoid stomach irritation, you can take delavirdine with food or with a full glass of water (unless your doctor tells you to do otherwise).


The tablets can be swallowed whole or dissolved in water (at least three ounces). If the tablets are dissolved in water, stir the mixture to keep the medication from settling to the bottom; take the mixture immediately. After taking the mixture, add more water to the glass to dissolve any remaining medication, and drink the water.

If your stomach does not secrete enough acid (a condition called achlorhydria), your doctor may want you to take delavirdine with an acidic beverage, such as orange juice or cranberry juice. Ask your doctor if this is necessary.

If you miss a dose of delavirdine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double the doses.

Side Effects :
Minor: Diarrhea, fatigue, headache, nausea, or vomiting. These side effects should diminish or disappear as your body adjusts to delavirdine.

Major: Tell your doctor about any side effects that are persistent or particularly bothersome. IT IS ESPECIALLY IMPORTANT TO TELL YOUR DOCTOR about difficulty breathing, rash, eye inflammation, fever, mouth sores, muscle or joint aches, severe or itching skin rash, or swelling.


Interactions :
Delavirdine may interact with a number of drugs:

Use of delavirdine with amphetamines, benzodiazepines, warfarin, calcium channel blockers, cisapride, or an ergot derivative may result in serious, life-threatening reactions.


Antacids or didanosine may block the absorption of delavirdine. At least one hour should separate the use of antacids or didanosine and delavirdine.


The effects of delavirdine may be reduced by carbamazepine, phenobarbital, phenytoin, rifabutin, rifampin, cimetidine, famotidine, nizatidine, or ranitidine.


The amount of clarithromycin or indinavir available in the body may be increased by delavirdine.

Warnings :
Tell your doctor if you have ever had an allergic reaction to delavirdine or to any other medication.


Before starting this medication, be sure to tell your doctor what medications you are taking. Delavirdine may have serious interactions with other drugs.


Before taking delavirdine, be sure to tell your doctor about any medical problems you may have, especially liver problems.
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